thyroid hormone receptor การใช้

• Certain mutations in the thyroid hormone receptor are associated with thyroid hormone resistance.
• The relationship is believed to take place at the thyroid hormone receptor level.
• T 3 in turn activates the thyroid hormone receptor which increases metabolic rate.
• TRIP11 has been shown to interact with Retinoblastoma protein and Thyroid hormone receptor alpha.
• Triiodothyronine binds to the thyroid hormone receptor in the formation of blood vessels and cell growth.
• These types of chemicals can act on androgen receptors, estrogen receptors and thyroid hormone receptors.
• The protein encoded by this gene interacts with thyroid hormone receptors and contains a jumonji domain.
• It is also a Rac3-interacting protein which acts as a corepressor for the thyroid hormone receptor.
• A molecular mechanism for non-genomic signaling through the nuclear thyroid hormone receptor TR? or any other nuclear receptors.
• The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation.
• TRIP11 was first identified through its ability to interact functionally with thyroid hormone receptor-beta ( THRB; MIM 190160 ).
• Type II nuclear receptors include principally subfamily 1, for example the retinoic acid receptor, retinoid X receptor and thyroid hormone receptor.
• These effects are mediated by specific nuclear receptor proteins that are members of the steroid and thyroid hormone receptor superfamily of transcriptional regulators.
• T3 could then bind to the thyroid hormone receptor in these neurons and affect the production of thyrotropin-releasing hormone, thereby regulating thyroid hormone production.
• The rev-Erb-? gene is highly unusual in that it is encoded on the opposite strand of the alpha-thyroid hormone receptor ( TR ) gene.
• Yet, since discovery of resistance to thyroid hormones in the absence of thyroid hormone receptor beta mutations, lack of a mutation in a patient does not rule out resistance.
• While the mechanism associated with the thyroid hormone receptor is not well understood, two more established mechanisms involve the inhibition of the androgen receptor and activation of the estrogen receptor.
• While at the EMBL in Heidelberg he cloned the c-erbA gene in 1984 and demonstrated in 1986 that the c-erbA gene encodes a high affinity thyroid hormone receptor.
• Independent of CDK, cyclin D1 binds to nuclear receptors ( including estrogen receptor ?, thyroid hormone receptor, PPAR? and AR ) to regulate cell proliferation, growth, and differentiation.
• In addition to participation in proteasome functions, this subunit may participate in transcriptional regulation since it has been shown to interact with the thyroid hormone receptor and retinoid X receptor-alpha.